Effects of homocysteine on vascular and tissue adenosine: a stake in homocysteine pathogenicity?
Identifieur interne : 000773 ( Main/Exploration ); précédent : 000772; suivant : 000774Effects of homocysteine on vascular and tissue adenosine: a stake in homocysteine pathogenicity?
Auteurs : Andreas Deussen [Allemagne] ; Annette Pexa [Allemagne] ; Robert Loncar [Allemagne] ; Sebastian N. Stehr [Allemagne]Source :
- Clinical Chemical Laboratory Medicine [ 1434-6621 ] ; 2005-10-01.
Abstract
Homocysteine may have deleterious effects on the cardiovascular system. It has been hypothesized that these effects may be brought about by a decrease in the adenosine concentration via the S-adenosylhomocysteine hydrolase reaction. A requirement for this causal relationship is proof of a reduction in vascular adenosine concentration during conditions of elevated homocysteine concentrations. In the present communication we summarize published data obtained during systematic variation of the arterial homocysteine concentration. Most of the results reported show that an increase in homocysteine concentration to 100 μM is associated with a 20–50% decrease in vascular adenosine concentration and an increase in tissue S-adenosylhomocysteine level. Homocysteine effects on the adenosine concentration seem to be more pronounced under conditions of impaired oxygenation. Further experiments, in particular on organs and tissue that release high amounts of homocysteine, i.e., the liver, are warranted to study the potential effects of homocysteine on vascular and tissue adenosine concentrations and consequent effects on organ function. The evidence obtained may be relevant for future assessment of risk indicators in conjunction with homocysteine pathogenicity, which might potentially be extended to measurements of adenosine or S-adenosylhomocysteine levels.
Url:
DOI: 10.1515/CCLM.2005.176
Affiliations:
- Allemagne
- District de Dresde, District de Düsseldorf, Rhénanie-du-Nord-Westphalie, Saxe (Land)
- Dresde, Düsseldorf
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It has been hypothesized that these effects may be brought about by a decrease in the adenosine concentration via the S-adenosylhomocysteine hydrolase reaction. A requirement for this causal relationship is proof of a reduction in vascular adenosine concentration during conditions of elevated homocysteine concentrations. In the present communication we summarize published data obtained during systematic variation of the arterial homocysteine concentration. Most of the results reported show that an increase in homocysteine concentration to 100 μM is associated with a 20–50% decrease in vascular adenosine concentration and an increase in tissue S-adenosylhomocysteine level. Homocysteine effects on the adenosine concentration seem to be more pronounced under conditions of impaired oxygenation. Further experiments, in particular on organs and tissue that release high amounts of homocysteine, i.e., the liver, are warranted to study the potential effects of homocysteine on vascular and tissue adenosine concentrations and consequent effects on organ function. The evidence obtained may be relevant for future assessment of risk indicators in conjunction with homocysteine pathogenicity, which might potentially be extended to measurements of adenosine or S-adenosylhomocysteine levels.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Dresde</li><li>District de Düsseldorf</li><li>Rhénanie-du-Nord-Westphalie</li><li>Saxe (Land)</li></region><settlement><li>Dresde</li><li>Düsseldorf</li></settlement></list><tree><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Deussen, Andreas" sort="Deussen, Andreas" uniqKey="Deussen A" first="Andreas" last="Deussen">Andreas Deussen</name></region><name sortKey="Loncar, Robert" sort="Loncar, Robert" uniqKey="Loncar R" first="Robert" last="Loncar">Robert Loncar</name><name sortKey="Pexa, Annette" sort="Pexa, Annette" uniqKey="Pexa A" first="Annette" last="Pexa">Annette Pexa</name><name sortKey="Stehr, Sebastian N" sort="Stehr, Sebastian N" uniqKey="Stehr S" first="Sebastian N." last="Stehr">Sebastian N. 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